Timing of Dietary Exposure and Breast Cancer Risk

Timing of Dietary Exposure and Breast Cancer Risk - MICROARRAY DATA

Lombardi Comprehensive Cancer Center
Department of Oncology
Georgetown University

Dr. Leena Hilakivi-Clarke

U54: The Timing of Dietary Exposure and Breast Cancer Risk

U54 Home Projects Login Investigators Links Publications Microarray Progress

3-D Projections of 20-Dimensional Data

The figures below show three-dimensional representations of 20 dimensional data, obtained using a variation of the visualization method described by Wang et al. (2000). The data represent molecular profiles obtained from the mammary glands of rats fed different diets; projections were generated as described in Ellis et al. (2002). The axes are derived from the top three principal components; the cumulative variance captured for each projection is shown. data. Rotation shows the separability of the gene expression profiles when projected into 3D space.

The graphics below are animated *.gif files and should rotate when viewed in either Netscape 4.7 or higher or MS Internet Explorer 5.0 or higher. These files tend to be better viewed in Netscape.

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Effects of n-3 (n=11; red) and n-6 (n=11; blue) on gene expression in rodent mammary glands

Top three principal component axes capture 74% of the cumulative variance in the data

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Effects of low fat (n-3 + n-6, n=13; red) and high fat (n-3 + n-6; n=9; blue) on gene expression in rodent mammary glands

Top three principal component axes capture 80% of the cumulative variance in the data

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Effects of low n-3 (n=6; blue), high n-3 (n=5; red circles) and all n-6 (n=11; red squares) on gene expression in rodent mammary glands

Top three principal component axes capture 96% of the cumulative variance in the data

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Other Links

Bioengineering Research Group - "Molecular analysis of breast cancer study."
Ellis et al. study - "Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses."
Gu et al. study - "Association of interferon regulatory factor-1, nucleophosmin, nuclear factor kappa-B, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780)" - a SAGE and gene expression microarray study.


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