Clarke Labs

Publications from Leena Hilakivi-Clarke's Laboratory
(See also Publications from Robert Clarke's Laboratory)

de Assis S, Khan G, Hilakivi-Clarke L. High birth weight increases mammary tumorigenesis in rats. Int J Cancer. 2006 Apr 27; [Epub ahead of print] PubMed
Trock BJ, Hilakivi-Clarke L, Clarke R. Meta-analysis of soy intake and breast cancer risk. J Natl Cancer Inst. 2006 Apr 5;98(7):459-71. PubMed
Hilakivi-Clarke L, Olivo SE, Shajahan A, Khan G, Zhu Y, Zwart A, Cho E, Clarke R. Mechanisms mediating the effects of prepubertal (n-3) polyunsaturated fatty acid diet on breast cancer risk in rats. J Nutr. 2005 Dec;135(12 Suppl):2946S-2952S. PubMed
L. Hilakivi-Clarke, G. Khan, C. Good, A. Cabanes. Early life dietary exposure to flaxseed increases later mammary tumorigenesis in rats. Submitted 2004.
L. Hilakivi-Clarke , R. Luoto, T. Huttunen, M. Koskenvuo. Body mass index, pregnancy weight gain and premenopausal breast cancer risk. Pending acceptance to the J Reproductive Med , 2004.
OP Soldin, L. Hilakivi-Clarke , E. Weiderpass, SJ Soldin. Trimerster-specific reference intervals for thyroxine and triiodothyroxine in pregnancy in ionide-sufficient women using isotope dilution tandem mass spectrometry and immunoassays. Clinica Chimica Acta , in press 2004
L. Hilakivi-Clarke , C. Wang, M. Kalil, R. Riggins, R.G. Pestell. Cell cycle control in breast cancer; the role of dietary intervention. Endocrine Related Cancer , accepted for publication after a revision, 2004.
T.I.Kinnunen, R. Luoto, E. Hemminki, M. Gissler, L. Hilakivi-Clarke . High pregnancy weight gain increases breast cancer risk. BMC Women's Health , accepted 2004.
A. Cabanes, M. Wang, S. Olivo, S. DeAssis, J. A. Gustafsson, G. Khan, and L. Hilakivi-Clarke . Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis 25 (5):741-748, 2004. PubMed Journal. PubMed
L. Hilakivi-Clarke , A. Cabanes, S. De Assis, M. Wang, G. Khan, W. J. Shoemaker, and R. G. Stevens. In utero alcohol exposure increases mammary tumorigenesis in rats. Br.J.Cancer 90 (11):2225-2231, 2004. PubMed
R. Clarke, M. C. Liu, K. B. Bouker, Z. Gu, R. Y. Lee, Y. Zhu, T. C. Skaar, B. Gomez, K. O'Brien, Y. Wang, and L. A. Hilakivi-Clarke . Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. Oncogene 22 (47):7316-7339, 2003. PubMed
M. D. Johnson, N. Kenney, A. Stoica, L. Hilakivi-Clarke , B. Singh, G. Chepko, R. Clarke, P. F. Sholler, A. A. Lirio, C. Foss, R. Reiter, B. Trock, S. Paik, and M. B. Martin. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat.Med. 9 (8):1081-1084, 2003. PubMed
K. I. Block, A. Constantinou, L. Hilakivi-Clarke , C. Hughes, D. Tripathy, and J. A. Tice. Point-counterpoint: soy intake for breast cancer patients. Integr.Cancer Ther. 1 (1):90-100, 2002. PubMed
L. Hilakivi-Clarke , E. Cho, A. Cabanes, S. DeAssis, S. Olivo, W. Helferich, M. E. Lippman, and R. Clarke. Dietary modulation of pregnancy estrogen levels and breast cancer risk among female rat offspring. Clin.Cancer Res. 8 (11):3601-3610, 2002. PubMed
L. Hilakivi-Clarke , A. Cabanes, S. Olivo, L. Kerr, K. B. Bouker, and R. Clarke. Do estrogens always increase breast cancer risk? J.Steroid Biochem.Mol.Biol. 80 (2):163-174, 2002. PubMed
C. C. Benz, L. Hilakivi-Clarke , S. Conzen, R. V. Dorn, G. F. Fleming, K. Grant, G. Greene, S. Hellman, C. Henderson, R. Hoover, W. Hryniuk, S. Jeffrey, M. Lippman, J. Lung, M. Mitchell, and M. Pike. Expedition inspiration consensus 2001. Breast Cancer Res.Treat. 70 (3):213-219, 2001. PubMed
R. Clarke, L. Hilakivi-Clarke , and B. Trock. Breast cancer: dietary and environmental oestrogens. Biologist (London) 48 (1):21-26, 2001. PubMed
L. Hilakivi-Clarke , E. Cho, S. DeAssis, S. Olivo, E. Ealley, K. B. Bouker, J. N. Welch, G. Khan, R. Clarke, and A. Cabanes. Maternal and prepubertal diet, mammary development and breast cancer risk. J.Nutr. 131 (1):154S-157S, 2001. PubMed
L. Hilakivi-Clarke , T. Forsen, J. G. Eriksson, R. Luoto, J. Tuomilehto, C. Osmond, and D. J. Barker. Tallness and overweight during childhood have opposing effects on breast cancer risk. Br.J.Cancer 85 (11):1680-1684, 2001. PubMed
R. G. Stevens and L. Hilakivi-Clarke . Alcohol exposure in utero and breast cancer risk later in life. Alcohol Alcohol 36 (3):276-277, 2001. PubMed
K. B. Bouker and L. Hilakivi-Clarke . Genistein: does it prevent or promote breast cancer? Environ.Health Perspect. 108 (8):701-708, 2000. PubMed
A. Cabanes, S. De Assis, J. A. Gustafsson, and L. Hilakivi-Clarke . Maternal high n-6 polyunsaturated fatty acid intake during pregnancy increases voluntary alcohol intake and hypothalamic estrogen receptor alpha and beta levels among female offspring. Dev.Neurosci. 22 (5-6):488-493, 2000. PubMed
L. Hilakivi-Clarke . Estrogens, BRCA1, and breast cancer. Cancer Res. 60 (18):4993-5001, 2000. PubMed
L. Hilakivi-Clarke , R. Clarke, and M. Lippman. The influence of maternal diet on breast cancer risk among female offspring. Nutrition 15 (5):392-401, 1999. PubMed
L. Hilakivi-Clarke , I. Onojafe, M. Raygada, E. Cho, T. Skaar, I. Russo, and R. Clarke. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Br.J.Cancer 80 (11):1682-1688, 1999. PubMed
L. Hilakivi-Clarke , E. Cho, I. Onojafe, M. Raygada, and R. Clarke. Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring. Oncol.Rep. 6 (5):1089-1095, 1999. PubMed
L. Hilakivi-Clarke , E. Cho, and R. Clarke. Maternal genistein exposure mimics the effects of estrogen on mammary gland development in female mouse offspring. Oncol.Rep. 5 (3):609-616, 1998. PubMed
L. Hilakivi-Clarke , A. Stoica, M. Raygada, and M. B. Martin. Consumption of a high-fat diet alters estrogen receptor content, protein kinase C activity, and mammary gland morphology in virgin and pregnant mice and female offspring. Cancer Res. 58 (4):654-660, 1998. PubMed
L. Hilakivi-Clarke and R. Clarke. Timing of dietary fat exposure and mammary tumorigenesis: role of estrogen receptor and protein kinase C activity. Mol.Cell Biochem. 188 (1-2):5-12, 1998. PubMed
M. Raygada, E. Cho, and L. Hilakivi-Clarke . High maternal intake of polyunsaturated fatty acids during pregnancy in mice alters offsprings' aggressive behavior, immobility in the swim test, locomotor activity and brain protein kinase C activity. J.Nutr. 128 (12):2505-2511, 1998. PubMed
P. Yenbutr, L. Hilakivi-Clarke , and A. Passaniti. Hypomethylation of an exon I estrogen receptor CpG island in spontaneous and carcinogen-induced mammary tumorigenesis in the rat. Mech.Ageing Dev. 106 (1-2):93-102, 1998. PubMed
L. Hilakivi-Clarke , R. Clarke, I. Onojafe, M. Raygada, E. Cho, and M. Lippman. A maternal diet high in n - 6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring. Proc.Natl.Acad.Sci.U.S.A 94 (17):9372-9377, 1997. PubMed
L. Hilakivi-Clarke , M. Raygada, and E. Cho. Serum estradiol levels and ethanol-induced aggression. Pharmacol.Biochem.Behav. 58 (3):785-791, 1997. PubMed
L. Hilakivi-Clarke . Mechanisms by which high maternal fat intake during pregnancy increases breast cancer risk in female rodent offspring. Breast Cancer Res.Treat. 46 (2-3):199-214, 1997. PubMed
L. Hilakivi-Clarke , E. Cho, and M. Raygada. Early postnatal treatment with transforming growth factor alpha does not alter nonreproductive behavior. Physiol Behav. 62 (1):207-211, 1997. PubMed
L. Hilakivi-Clarke . Estrogen-regulated non-reproductive behaviors and breast cancer risk: animal models and human studies. Breast Cancer Res.Treat. 46 (2-3):143-159, 1997. PubMed
L. Hilakivi-Clarke . Maternal handling during pregnancy reduces DMBA-induced mammary tumorigenesis among female offspring. Br.J.Cancer 76 (2):150-155, 1997. PubMed
L. Hilakivi-Clarke , E. Cho, M. Raygada, and N. Kenney. Alterations in mammary gland development following neonatal exposure to estradiol, transforming growth factor alpha, and estrogen receptor antagonist ICI 182,780. J.Cell Physiol 170 (3):279-289, 1997. PubMed
R. Clarke, L. Hilakivi-Clarke , E. Cho, M. R. James, and F. Leonessa. Estrogens, phytoestrogens, and breast cancer. Adv.Exp.Med.Biol. 401:63-85, 1996. PubMed
L. Hilakivi-Clarke , E. Cho, and I. Onojafe. High-fat diet induces aggressive behavior in male mice and rats. Life Sci. 58 (19):1653-1660, 1996. PubMed
L. Hilakivi-Clarke , I. Onojafe, M. Raygada, E. Cho, R. Clarke, and M. E. Lippman. Breast cancer risk in rats fed a diet high in n-6 polyunsaturated fatty acids during pregnancy. J.Natl.Cancer Inst. 88 (24):1821-1827, 1996. PubMed
L. Hilakivi-Clarke . Role of estradiol in alcohol intake and alcohol-related behaviors. J.Stud.Alcohol 57 (2):162-170, 1996. PubMed
L. Hilakivi-Clarke , E. Cho, M. Raygada, I. Onojafe, R. Clarke, and M. E. Lippman. Early life affects the risk of developing breast cancer. Ann.N.Y.Acad.Sci. 768:327-330, 1995. PubMed
L. Hilakivi-Clarke and R. B. Dickson. Stress influence on development of hepatocellular tumors in transgenic mice overexpressing TGF alpha. Acta Oncol. 34 (7):907-912, 1995. PubMed
L. Hilakivi-Clarke and R. Goldberg. Gonadal hormones and aggression-maintaining effect of alcohol in male transgenic transforming growth factor-alpha mice. Alcohol Clin.Exp.Res. 19 (3):708-713, 1995. PubMed
L. A. Hilakivi-Clarke , T. D. Corduban, T. Taira, A. Hitri, S. Deutsch, E. R. Korpi, R. Goldberg, and K. J. Kellar. Alterations in brain monoamines and GABAA receptors in transgenic mice overexpressing TGF alpha. Pharmacol.Biochem.Behav. 50 (4):593-600, 1995. PubMed
L. Hilakivi-Clarke . Overexpression of transforming growth factor alpha in transgenic mice alters nonreproductive, sex-related behavioral differences: interaction with gonadal hormones. Behav.Neurosci. 108 (2):410-417, 1994. PubMed
L. Hilakivi-Clarke , R. Clarke, and M. E. Lippman. Perinatal factors increase breast cancer risk. Breast Cancer Res.Treat. 31 (2-3):273-284, 1994. PubMed
L. Hilakivi-Clarke , J. Rowland, R. Clarke, and M. E. Lippman. Psychosocial factors in the development and progression of breast cancer. Breast Cancer Res.Treat. 29 (2):141-160, 1994. PubMed
M. Korkman, L. A. Hilakivi-Clarke , I. Autti-Ramo, V. Fellman, and M. L. Granstrom. Cognitive impairments at two years of age after prenatal alcohol exposure or perinatal asphyxia. Neuropediatrics 25 (2):101-105, 1994. PubMed
L. Hilakivi-Clarke , A. Wright, and M. E. Lippman. DMBA-induced mammary tumor growth in rats exhibiting increased or decreased ability to cope with stress due to early postnatal handling or antidepressant treatment. Physiol Behav. 54 (2):229-236, 1993. PubMed
L. Hilakivi-Clarke , M. Durcan, and R. Goldberg. Effect of alcohol on elevated aggressive behavior in male transgenic TGF alpha mice. Neuroreport 4 (2):155-158, 1993. PubMed
L. A. Hilakivi-Clarke and R. Goldberg. Effects of tryptophan and serotonin uptake inhibitors on behavior in male transgenic transforming growth factor alpha mice. Eur.J.Pharmacol. 237 (1):101-108, 1993. PubMed
L. A. Hilakivi-Clarke , P. K. Arora, R. Clarke, A. Wright, M. E. Lippman, and R. B. Dickson. Opposing behavioural alterations in male and female transgenic TGF alpha mice: association with tumour susceptibility. Br.J.Cancer 67 (5):1026-1030, 1993. PubMed
I. Autti-Ramo, M. Korkman, L. Hilakivi-Clarke , M. Lehtonen, E. Halmesmaki, and M. L. Granstrom. Mental development of 2-year-old children exposed to alcohol in utero. J.Pediatr. 120 (5):740-746, 1992. PubMed
L. Hilakivi-Clarke . [Psychosocial factors and breast cancer]. Duodecim 108 (7):626-637, 1992. PubMed
L. Hilakivi-Clarke and R. G. Lister. Social status and voluntary alcohol consumption in mice: interaction with stress. Psychopharmacology (Berl) 108 (3):276-282, 1992. PubMed
L. A. Hilakivi-Clarke and R. G. Lister. Are there preexisting behavioral characteristics that predict the dominant status of male NIH Swiss mice (Mus musculus)? J.Comp Psychol. 106 (2):184-189, 1992. PubMed
L. A. Hilakivi-Clarke . Injection of vehicle is not a stressor in Porsolt's swim test. Pharmacol.Biochem.Behav. 42 (1):193-196, 1992. PubMed
L. A. Hilakivi-Clarke , P. K. Arora, M. B. Sabol, R. Clarke, R. B. Dickson, and M. E. Lippman. Alterations in behavior, steroid hormones and natural killer cell activity in male transgenic TGF alpha mice. Brain Res. 588 (1):97-103, 1992. PubMed
L. A. Hilakivi-Clarke . Effects of tryptophan on depression and aggression in STZ-D mice. Diabetes 40 (12):1598-1602, 1991. PubMed
L. A. Hilakivi-Clarke , J. Turkka, R. G. Lister, and M. Linnoila. Effects of early postnatal handling on brain beta-adrenoceptors and behavior in tests related to stress. Brain Res. 542 (2):286-292, 1991. PubMed
L. A. Hilakivi-Clarke , K. M. Wozniak, M. J. Durcan, and M. Linnoila. Behavior of streptozotocin-diabetic mice in tests of exploration, locomotion, anxiety, depression and aggression. Physiol Behav. 48 (3):429-433, 1990. PubMed
L. A. Hilakivi-Clarke , M. J. Durcan, R. G. Lister, and M. Linnoila. Effect of tryptophan on the behavior of nonstressed and stressed mice in Porsolt's swim test. Pharmacol.Biochem.Behav. 37 (2):273-276, 1990. PubMed
E. R. Korpi, P. Paivarinta, A. Abi-Dargham, A. Honkanen, M. Laruelle, K. Tuominen, and L. A. Hilakivi . Binding of serotonergic ligands to brain membranes of alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol 9 (5):369-374, 1992. PubMed
L. A. Hilakivi and R. G. Lister. Correlations between behavior of mice in Porsolt's swim test and in tests of anxiety, locomotion, and exploration. Behav.Neural Biol. 53 (2):153-159, 1990. PubMed
T. Taira, L. A. Hilakivi , J. Aalto, and I. Hilakivi. Effect of beta-casomorphin on neonatal sleep in rats. Peptides 11 (1):1-4, 1990. PubMed
K. Tuominen, L. A. Hilakivi , P. Paivarinta, and E. R. Korpi. Behavior of alcohol-preferring AA and alcohol-avoiding ANA rat lines in tests of anxiety and aggression. Alcohol 7 (4):349-353, 1990. PubMed
M. J. Durcan, L. A. Hilakivi , R. G. Lister, and M. Linnoila. Attenuation of the effects of ethanol on social behavior by alpha 2-adrenoceptor antagonists. Alcohol 6 (3):189-192, 1989. PubMed
J. Fernandez-Pardal and L. A. Hilakivi . Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs. Alcohol 6 (2):93-95, 1989. PubMed
L. A. Hilakivi , M. Ota, and R. G. Lister. Effect of isolation on brain monoamines and the behavior of mice in tests of exploration, locomotion, anxiety and behavioral 'despair'. Pharmacol.Biochem.Behav. 33 (2):371-374, 1989. PubMed
L. A. Hilakivi , M. J. Durcan, and R. G. Lister. Effects of caffeine on social behavior, exploration and locomotor activity: interactions with ethanol. Life Sci. 44 (8):543-553, 1989. PubMed
L. A. Hilakivi and R. G. Lister. Effect of ethanol on the social behavior of group-housed and isolated mice. Alcohol Clin.Exp.Res. 13 (5):622-625, 1989. PubMed
L. A. Hilakivi , R. G. Lister, M. J. Durcan, M. Ota, R. L. Eskay, I. Mefford, and M. Linnoila. Behavioral, hormonal and neurochemical characteristics of aggressive alpha-mice. Brain Res. 502 (1):158-166, 1989. PubMed
L. A. Hilakivi , M. J. Durcan, and R. G. Lister. Effects of ethanol on fight- or swim-stressed mice in Porsolt's swim test. Neuropsychopharmacology 2 (4):293-298, 1989. PubMed
I. Hilakivi, T. Taira, and L. A. Hilakivi . Effect of peripheral administration of arginine vasotocin on neonatal sleep in rats. Peptides 9 (3):487-491, 1988. PubMed
L. A. Hilakivi , T. Taira, and I. Hilakivi. Early postnatal deprivation of active sleep with desipramine or zimeldine impairs later behavioural reactivity to auditory stimuli in rats. Acta Physiol Scand. 132 (2):191-198, 1988. PubMed
L. A. Hilakivi , T. Taira, I. Hilakivi, and P. Loikas. Neonatal treatment with monoamine uptake inhibitors alters later response in behavioural 'despair' test to beta and GABA-B receptor agonists. Pharmacol.Toxicol. 63 (1):57-61, 1988. PubMed
L. A. Hilakivi and R. G. Lister. RO 15-4513 and FG 7142 reverse the reduction in social behavior caused by ethanol in mice. Eur.J.Pharmacol. 154 (1):109-113, 1988. PubMed
L. A. Hilakivi , T. Taira, I. Hilakivi, E. MacDonald, L. Tuomisto, and K. Hellevuo. Early postnatal treatment with propranolol affects development of brain amines and behavior. Psychopharmacology (Berl) 96 (3):353-359, 1988. PubMed
R. G. Lister and L. A. Hilakivi . The effects of novelty, isolation, light and ethanol on the social behavior of mice. Psychopharmacology (Berl) 96 (2):181-187, 1988. PubMed
L. Hilakivi-Clarke , L. Tuomisto, I. Hilakivi, K. Kiianmaa, K. Hellevuo, and P. Hyytia. Effect of prenatal alcohol exposure on neonatal sleep-wake behaviour and adult alcohol consumption in the AA and ANA rat lines. Alcohol Alcohol 22 (3):231-240, 1987. PubMed
L. Hilakivi-Clarke . Adult alcohol consumption after pharmacological intervention in neonatal sleep. Acta Physiol Scand.Suppl 562:1-58, 1987. PubMed
L. Hilakivi-Clarke . Sleeping and dreams in learning-disabled boys. Acta Psychiatr.Scand. 76 (1):103-105, 1987. PubMed
L. A. Hilakivi , D. Stenberg, J. D. Sinclair, and K. Kiianmaa. Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats. Psychopharmacology (Berl) 91 (4):403-409, 1987. PubMed
L. A. Hilakivi , I. Hilakivi, and K. Kiianmaa. Neonatal antidepressant administration suppresses concurrent active (REM) sleep and increases adult alcohol consumption in rats. Alcohol Alcohol Suppl 1:339-343, 1987. PubMed
L. A. Hilakivi , I. Hilakivi, L. Ahtee, H. Haikala, and M. Attila. Effect of neonatal nomifensine exposure on adult behavior and brain monoamines in rats. J.Neural Transm. 70 (1-2):99-116, 1987. PubMed
L. A. Hilakivi and I. Hilakivi. Increased adult behavioral 'despair' in rats neonatally exposed to desipramine or zimeldine: an animal model of depression? Pharmacol.Biochem.Behav. 28 (3):367-369, 1987. PubMed
J. Aalto and L. Hilakivi-Clarke . Differences in the sleep-wake patterns of the AA and ANA rat lines developed for high and low alcohol intake. Alcohol 3 (1):77-79, 1986. PubMed
L. Hilakivi-Clarke and I. Hilakivi. [Minimal brain dysfunction--neurobiological approach]. Duodecim 102 (1):17-25, 1986. PubMed
L. Hilakivi-Clarke and J. D. Sinclair. Effect of neonatal clomipramine treatment on adult alcohol drinking in the AA and ANA rat lines. Pharmacol.Biochem.Behav. 24 (5):1451-1455, 1986. PubMed
L. Hilakivi-Clarke . Effects of prenatal alcohol exposure on neonatal sleep-wake behaviour and adult alcohol consumption in rats. Acta Pharmacol.Toxicol.(Copenh) 59 (1):36-42, 1986. PubMed
L. A. Hilakivi and I. T. Hilakivi. Sleep-wake behavior of newborn rats recorded with movement sensitive method. Behav.Brain Res. 19 (3):241-248, 1986. PubMed
L. Hilakivi-Clarke and E. Hirsjarvi. [Aging and sleep]. Duodecim 101 (6):551-560, 1985. PubMed
L. Hilakivi-Clarke , C. J. Eriksson, M. Sarviharju, and J. D. Sinclair. Revitalization of the AA and ANA rat lines: effects on some line characteristics. Alcohol 1 (1):71-75, 1984. PubMed
L. A. Hilakivi , J. D. Sinclair, and I. T. Hilakivi. Effects of neonatal treatment with clomipramine on adult ethanol related behavior in the rat. Brain Res. 317 (1):129-132, 1984. PubMed