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Dr. Clarke's research interests include understanding the cellular and molecular mechanisms driving antiestrogen resistance and hormone independence in breast cancer. He also is interested in drug resistance (cytotoxic, endocrine, chemopreventive agents), drug/hormone interactions, and the application of molecular profiling ( e.g., gene expression microarrays, serial analysis of gene expression, tissue arrays) to predict breast cancer phenotypes and identify functionally relevant gene signaling networks.
Dr. Clarke is Co-Director of the Breast Cancer Program at the Lombardi Comprehensive Cancer Center
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Dr. Hilakivi-Clarke's research interests include understanding the importance of timing of exposure to estrogens, phytoestrogens, and other dietary/nutrition components on the programming of mammary gland development and its effects on breast cancer susceptibility. She also is active in exploring gene-nutrient interactions and their role in affecting breast cancer risk and progression.
Dr. Hilakivi-Clarkeis Co-Director of the Division of Molecular Endocrinology, Nutrition and Obesity.
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